MAPK6

Across TCGA cell cohorts, MAPK6 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. OESOPHAGUS shows the largest number of these associations.

The most reproducible MAPK6-associated genes across cancer lineages are SLC35G3, OR9K2, and OR1L6. Each is linked with MAPK6 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAPK6-to-partner and partner-to-MAPK6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC35G3 grouped by MAPK6-low versus MAPK6-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAPK6→partner) and Y-score (partner→MAPK6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SLC35G3 →	+0.011	+4.017	<.001	.007	3	2
PANCREAS	OR9K2 →	+0.013	+5.614	<.001	.002	3	1
PANCREAS	OR1L6 →	+0.019	+5.000	<.001	.006	3	1
OESOPHAGUS	RS1 →	+0.012	+4.857	<.001	<.001	3	1
OESOPHAGUS	RHOXF2 →	+0.026	+4.392	<.001	.003	3	1
STOMACH	KRTAP21-3 →	+0.513	+5.285	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

SLC35G3 by MAPK6 expression — OESOPHAGUS

Explore this box plot interactively →