MAPK6

Across TCGA pan-cancer cohorts, MAPK6 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of MAPK6’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where MAPK6 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MAPK6 is over-expressed in tumor, although a few such as COAD and READ show the opposite, repressed pattern.

HNSC, LIHC, and LUSC are the cancer types where MAPK6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MAPK6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+1.258	<.001	12	view →
LIHC	Male	All	+0.731	<.001	9	view →
LUSC	Female	All	+1.607	<.001	8	view →
LUAD	Male	II,III,IV	+1.183	<.001	8	view →
UCEC	All	III,IV	+1.046	.007	6	view →
COAD	All	All	−0.684	<.001	6	view →
BRCA	All	II,III,IV	+0.351	<.001	4	view →
KIRC	All	All	+0.214	.013	4	view →
READ	All	All	−0.796	.006	2	view →
KICH	Female	All	−0.777	.003	2	view →
STAD	All	All	+0.601	.014	2	view →
PRAD	All	All	+0.551	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

MAPK6–HNSC

Open the HNSC breakdown →