MAPK15

Across TCGA patient cohorts, MAPK15 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAPK15-associated genes across cancer lineages are N-Cadherin, p90 RSK, and ARID1A. Each is linked with MAPK15 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAPK15-to-partner and partner-to-MAPK15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, N-Cadherin grouped by MAPK15-low versus MAPK15-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAPK15→partner) and Y-score (partner→MAPK15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	N-Cadherin →	-0.208	-2.000	.029	.032	3	1
UCEC	p90 RSK →	+0.218	+2.469	.011	.010	3	1
UCEC	ARID1A →	-0.192	-2.452	.028	.020	3	1
UCEC	Bcl-xL →	-0.198	-3.807	.005	<.001	2	1
UCEC	c-Kit →	-0.266	-2.700	.011	.006	2	1
UCEC	eIF4E →	+0.218	+2.000	.022	.032	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

N-Cadherin by MAPK15 expression — UCEC

Explore this box plot interactively →