MAPK15

Across TCGA pan-cancer cohorts, MAPK15 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated MAPK15 data layer compared with 6 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher MAPK15 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated MAPK15 expression acts as an unfavorable survival marker, although some lineages such as HNSC and KIRP show a favorable association.

COAD, ACC, and HNSC are the cancer types where MAPK15 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Tertile	II,III,IV	0.701	0.870	<.001	89	view →
ACC	DFS	Median	All	0.289	0.618	<.001	70	view →
HNSC	OS	Median	IV	0.774	0.638	.004	30	view →
KIRP	DFS	Median	II,III,IV	0.911	0.549	.021	22	view →
PRAD	DFS	Median	All	0.831	0.930	<.001	18	view →
LGG	DFS	Quartile	All	0.280	0.572	<.001	12	view →
LIHC	OS	Tertile	All	0.875	0.682	.004	11	view →
KIRC	DFS	Tertile	IV	0.336	0.543	.013	10	view →
BRCA	DFS	Median	IV	0.737	0.399	.024	8	view →
DLBC	DFS	Median	All	0.672	1.000	.036	8	view →
SCLC	DFS	Quartile	II,III,IV	0.831	0.219	.024	7	view →
OV	OS	Tertile	IV	0.280	0.548	.008	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

MAPK15–COAD (OS)

Open the COAD breakdown →