MAPK15

Across TCGA cell cohorts, MAPK15 mutation is significantly associated with the RNA expression of many other genes, with 725 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MAPK15-associated genes across cancer lineages are LYG1, OR8B4, and CACTIN. Each is linked with MAPK15 in more than 2 cancer types. Because this analysis shows association rather than direction, both MAPK15-to-partner and partner-to-MAPK15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LYG1 grouped by MAPK15-low versus MAPK15-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAPK15→partner) and Y-score (partner→MAPK15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LYG1 →	+0.852	+3.364	.002	.002	3	3
OESOPHAGUS	OR8B4 →	+0.036	+4.906	<.001	.006	3	2
LARGE_INTESTINE	CACTIN →	+0.573	+3.364	.002	.002	3	2
LARGE_INTESTINE	VPS4A →	+0.453	+3.364	.006	.002	3	2
LARGE_INTESTINE	FEM1A →	+0.644	+3.082	<.001	.007	3	2
LARGE_INTESTINE	GKAP1 →	+0.747	+3.364	.002	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 725 associations by consensus.

LYG1 by MAPK15 expression — LARGE_INTESTINE

Explore this box plot interactively →