MAPK13

Across TCGA patient cohorts, MAPK13 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible MAPK13-associated genes across cancer lineages are EGFR_pY1068, FOXO3a, and p53. Each is linked with MAPK13 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAPK13-to-partner and partner-to-MAPK13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by MAPK13-low versus MAPK13-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAPK13→partner) and Y-score (partner→MAPK13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	EGFR_pY1068 →	+0.153	+2.476	.049	.010	3	1
SKCM	FOXO3a →	+0.132	+3.000	.016	.034	3	1
SKCM	p53 →	+0.253	+2.820	.004	.035	3	1
SKCM	PARP_cleaved →	+0.150	+3.169	.045	.018	3	1
SKCM	Caspase-8 →	-0.158	-2.459	.022	.020	3	1
SKCM	CD49b →	+0.319	+2.476	.004	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

EGFR_pY1068 by MAPK13 expression — SKCM

Explore this box plot interactively →