MAPK1

Across TCGA patient cohorts, MAPK1 mutation is significantly associated with the RNA expression of many other genes, with 2,317 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAPK1-associated genes across cancer lineages are SNORD82, LINC01986, and RN7SKP43. Each is linked with MAPK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAPK1-to-partner and partner-to-MAPK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNORD82 grouped by MAPK1-low versus MAPK1-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAPK1→partner) and Y-score (partner→MAPK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	SNORD82 →	+0.526	+5.447	<.001	.005	3	2
GBM	LINC01986 →	+0.265	+5.584	<.001	.003	3	2
GBM	RN7SKP43 →	+0.203	+5.352	<.001	.005	3	2
SKCM	ATP6V1G1P4 →	+0.192	+4.032	.002	.005	3	2
HNSC	RNU6-339P →	+0.368	+4.736	<.001	.007	3	2
HNSC	RPL22P14 →	+0.171	+4.847	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,317 associations by consensus.

SNORD82 by MAPK1 expression — LIHC

Explore this box plot interactively →