MAP3K8

Across TCGA patient cohorts, MAP3K8 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAP3K8-associated genes across cancer lineages are eIF4E, c-Kit, and Di-Ras3. Each is linked with MAP3K8 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAP3K8-to-partner and partner-to-MAP3K8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by MAP3K8-low versus MAP3K8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP3K8→partner) and Y-score (partner→MAP3K8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.198	+2.000	.007	.003	3	2
UCEC	c-Kit →	-0.183	-1.861	.026	.049	3	2
UCEC	Di-Ras3 →	-0.124	-1.662	.017	.011	3	2
UCEC	EGFR_pY1068 →	-0.245	-2.392	.005	<.001	3	1
UCEC	A-Raf_pS299 →	-0.115	-1.807	.006	.025	3	1
UCEC	Fibronectin →	-0.231	-1.575	.047	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

eIF4E by MAP3K8 expression — UCEC

Explore this box plot interactively →