MAP3K8

Across TCGA cell cohorts, MAP3K8 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,913 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MAP3K8-associated GO terms across cancer lineages are Small GTPase-mediated signal transduction, Response to cold, and Activation of innate immune response. Each is linked with MAP3K8 in more than 8 cancer types. Because this analysis shows association rather than direction, both MAP3K8-to-partner and partner-to-MAP3K8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Small GTPase-mediated signal transduction grouped by MAP3K8-low versus MAP3K8-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP3K8→partner) and Y-score (partner→MAP3K8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Small GTPase-mediated signal transduction →	+0.045	+1.132	<.001	<.001	3	9
URINARY_TRACT	Response to cold →	+0.159	+1.305	.002	.002	3	8
BLOOD_Lymphoma	Activation of innate immune response →	+0.047	+1.380	.001	<.001	3	8
PANCREAS	Cytoplasmic pattern recognition receptor signaling pathway →	+0.071	+1.165	.002	.001	3	8
BLOOD_Lymphoma	Homotypic cell-cell adhesion →	+0.097	+1.153	.004	.006	3	8
BLOOD_Lymphoma	Positive regulation of CD4-positive, alpha-beta T cell differentiation →	+0.062	+1.165	.009	.005	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,913 associations by consensus.

Small GTPase-mediated signal transduction by MAP3K8 expression — URINARY_TRACT

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