MAP3K3

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, MAP3K3 mutation is significantly associated with the RNA expression of many other genes, with 4,433 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAP3K3-associated genes across cancer lineages are RN7SL62P, RNU6-819P, and RN7SL248P. Each is linked with MAP3K3 in more than 2 cancer types. Because this analysis shows association rather than direction, both MAP3K3-to-partner and partner-to-MAP3K3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP3K3→partner) and Y-score (partner→MAP3K3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
CESCRN7SL62P →+0.112+4.812<.001.00633
LUADRNU6-819P →+0.415+3.756<.001.00132
LUADRN7SL248P →+0.067+4.263<.001.00732
UCECOXSM →+0.309+2.169<.001.00232
UCECCXADR →+0.573+1.389.001.00532
UCECANKRD9 →+0.425+4.075<.001<.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 4,433 associations by consensus.

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