MAP3K15

Across TCGA patient cohorts, MAP3K15 mutation is significantly associated with the RNA expression of many other genes, with 5,272 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAP3K15-associated genes across cancer lineages are OR8X1P, COQ5, and SNRPD1. Each is linked with MAP3K15 in more than 3 cancer types. Because this analysis shows association rather than direction, both MAP3K15-to-partner and partner-to-MAP3K15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR8X1P grouped by MAP3K15-low versus MAP3K15-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP3K15→partner) and Y-score (partner→MAP3K15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	OR8X1P →	+0.021	+2.557	.001	.004	3	4
UCEC	COQ5 →	+0.207	+1.225	.004	.004	3	4
UCEC	SNRPD1 →	+0.256	+1.010	.006	.004	3	4
UCEC	TXNL4A →	+0.232	+1.147	.003	.001	3	4
SKCM	NOC4L →	+0.321	+1.839	.009	.002	3	4
SKCM	FKBP3 →	+0.393	+1.839	.004	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,272 associations by consensus.

OR8X1P by MAP3K15 expression — SKCM

Explore this box plot interactively →