MAP3K15

Across TCGA pan-cancer cohorts, MAP3K15 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated MAP3K15 data layer compared with 10 for mutation status.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher MAP3K15 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MAP3K15 expression acts as an unfavorable survival marker, although some lineages such as SCLC and UCS show a favorable association.

KIRP, KIRC, and UCEC are the cancer types where MAP3K15 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Tertile	All	0.342	0.691	<.001	141	view →
KIRC	DFS	Median	II,III,IV	0.412	0.634	<.001	112	view →
UCEC	DFS	Median	All	0.550	0.742	<.001	86	view →
SCLC	OS	Quartile	II,III,IV	0.703	0.223	<.001	82	view →
KICH	OS	Quartile	II,III,IV	0.481	1.000	<.001	46	view →
LGG	DFS	Median	All	0.673	0.802	<.001	42	view →
COAD	DFS	Median	All	0.595	0.754	.004	34	view →
UCS	OS	Quartile	III,IV	0.766	0.302	.018	26	view →
BRCA	DFS	Tertile	IV	0.353	0.814	.012	21	view →
PAAD	DFS	Tertile	All	0.531	0.230	.001	20	view →
ESCA	OS	Tertile	All	0.376	0.550	.011	18	view →
SARC	OS	Quartile	All	0.743	0.878	.005	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

MAP3K15–KIRP (DFS)

Open the KIRP breakdown →