MAP3K15

Across TCGA pan-cancer cohorts, MAP3K15 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of MAP3K15’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where MAP3K15 RNA is repressed in tumor relative to normal tissue. In most cancer types MAP3K15 is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

KIRC, THCA, and LUAD are the cancer types where MAP3K15 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MAP3K15 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−1.968	<.001	12	view →
THCA	Female	All	−0.148	<.001	9	view →
LUAD	Female	III,IV	−1.057	<.001	8	view →
LUSC	Female	II,III,IV	−0.988	<.001	8	view →
BRCA	All	III,IV	−0.188	<.001	8	view →
COAD	All	All	−0.065	<.001	8	view →
KIRP	Male	All	−1.188	<.001	6	view →
KICH	All	All	−1.310	<.001	5	view →
LIHC	All	All	+0.191	.005	3	view →
HNSC	Female	IV	−0.141	.026	3	view →
PRAD	All	All	−0.052	.004	2	view →
READ	All	II,III,IV	−0.117	.036	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

MAP3K15–KIRC

Open the KIRC breakdown →