MAP3K15

Across TCGA patient cohorts, MAP3K15 mutation is significantly associated with the total protein of many other genes, with 60 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAP3K15-associated genes across cancer lineages are Chk1, Annexin-1, and ASNS. Each is linked with MAP3K15 in more than 2 cancer types. Because this analysis shows association rather than direction, both MAP3K15-to-partner and partner-to-MAP3K15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Chk1 grouped by MAP3K15-low versus MAP3K15-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP3K15→partner) and Y-score (partner→MAP3K15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	Chk1 →	+0.304	+2.179	.001	.035	3	3
UCEC	Annexin-1 →	+0.458	+2.000	<.001	<.001	3	3
COAD	ASNS →	+0.647	+3.178	<.001	.010	3	3
UCEC	ATM →	-0.343	-1.912	.002	.004	3	3
COAD	TSC1 →	-0.469	-3.000	<.001	.034	3	3
LUSC	53BP1 →	-0.464	-3.312	.018	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 60 associations by consensus.

Chk1 by MAP3K15 expression — LUSC

Explore this box plot interactively →