MAP3K15

Across TCGA cell cohorts, MAP3K15 mutation is significantly associated with the RNA expression of many other genes, with 78 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MAP3K15-associated genes across cancer lineages are OR9A2, SERPINA12, and ACSM6. Each is linked with MAP3K15 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAP3K15-to-partner and partner-to-MAP3K15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR9A2 grouped by MAP3K15-low versus MAP3K15-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP3K15→partner) and Y-score (partner→MAP3K15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	OR9A2 →	+0.022	+5.209	<.001	.005	3	2
BONE	SERPINA12 →	+0.125	+3.672	<.001	.004	3	1
BONE	ACSM6 →	+0.060	+3.688	<.001	.007	3	1
BONE	TREML4 →	+0.178	+3.688	<.001	.007	3	1
BONE	PRB3 →	+0.216	+4.146	<.001	.002	3	1
BONE	OR4M2 →	+0.067	+4.129	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 78 associations by consensus.

OR9A2 by MAP3K15 expression — BLOOD_Lymphoma

Explore this box plot interactively →