MAP3K14

Across TCGA patient cohorts, MAP3K14 mutation is significantly associated with the RNA expression of many other genes, with 1,924 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAP3K14-associated genes across cancer lineages are MFAP1, RITA1, and AP2B1. Each is linked with MAP3K14 in more than 3 cancer types. Because this analysis shows association rather than direction, both MAP3K14-to-partner and partner-to-MAP3K14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MFAP1 grouped by MAP3K14-low versus MAP3K14-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP3K14→partner) and Y-score (partner→MAP3K14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MFAP1 →	+0.485	+2.955	.001	<.001	3	4
UCEC	RITA1 →	+0.460	+1.801	<.001	.004	3	3
UCEC	AP2B1 →	+0.585	+3.884	<.001	<.001	3	3
CESC	BUB3P1 →	+0.032	+2.364	.006	.007	3	3
COAD	OIP5 →	+0.693	+3.479	<.001	.002	3	3
COAD	ZWINT →	+0.531	+3.489	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,924 associations by consensus.

MFAP1 by MAP3K14 expression — UCEC

Explore this box plot interactively →