MAP3K14

Across TCGA pan-cancer cohorts, MAP3K14 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of MAP3K14’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where MAP3K14 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MAP3K14 is over-expressed in tumor, although a few such as KICH and HNSC show the opposite, repressed pattern.

KIRC, KICH, and HNSC are the cancer types where MAP3K14 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MAP3K14 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+1.665	<.001	12	view →
KICH	Female	II,III,IV	−2.560	<.001	10	view →
HNSC	All	II,III,IV	−0.497	<.001	9	view →
BLCA	Male	III,IV	−1.112	<.001	8	view →
UCEC	All	All	−1.178	<.001	6	view →
KIRP	Female	All	+0.935	.002	6	view →
BRCA	Female	II,III,IV	−0.517	<.001	6	view →
LUAD	All	All	−0.645	<.001	5	view →
LUSC	Male	All	−0.627	<.001	4	view →
LIHC	All	II,III,IV	+0.599	.032	3	view →
CHOL	Male	All	+1.290	.001	2	view →
ESCA	All	All	+0.898	.017	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

MAP3K14–KIRC

Open the KIRC breakdown →