MAP1S

Across TCGA patient cohorts, MAP1S mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. COAD shows the largest number of these associations.

The most reproducible MAP1S-associated genes across cancer lineages are Caspase-7-cleavedD198, HSP70, and XBP1. Each is linked with MAP1S in more than 2 cancer types. Because this analysis shows association rather than direction, both MAP1S-to-partner and partner-to-MAP1S results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by MAP1S-low versus MAP1S-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP1S→partner) and Y-score (partner→MAP1S) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.389	+3.186	<.001	.009	3	3
COAD	HSP70 →	+0.606	+2.820	.023	.035	3	2
COAD	XBP1 →	+0.182	+2.178	.041	.035	3	2
COAD	C-Raf →	+0.137	+2.178	.045	.035	3	2
COAD	Cyclin-E2 →	+0.246	+2.832	.024	.034	3	2
UCEC	MEK1 →	+0.345	+2.321	.016	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

Caspase-7-cleavedD198 by MAP1S expression — COAD

Explore this box plot interactively →