MAOB

Across TCGA patient cohorts, MAOB mutation is significantly associated with the RNA expression of many other genes, with 2,854 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAOB-associated genes across cancer lineages are MIR3908, LINC01943, and IGKV1D-43. Each is linked with MAOB in more than 2 cancer types. Because this analysis shows association rather than direction, both MAOB-to-partner and partner-to-MAOB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR3908 grouped by MAOB-low versus MAOB-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAOB→partner) and Y-score (partner→MAOB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR3908 →	+0.282	+5.112	<.001	.004	3	3
UCEC	LINC01943 →	+0.402	+1.676	<.001	.001	3	2
LIHC	IGKV1D-43 →	+0.756	+3.665	.003	.007	3	2
BRCA	FAM223B →	+0.082	+5.505	<.001	.002	3	2
UCEC	CD37 →	+0.539	+3.000	.003	.001	3	2
UCEC	OAZ1 →	+0.546	+2.245	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,854 associations by consensus.

MIR3908 by MAOB expression — BRCA

Explore this box plot interactively →