family with sequence similarity 223 member BGenealiases: CXorf52 · CXorf52B · LINC00204B · NCRNA00204B
Q-omics provides the consensus-scored FAM223B profile across patient tissues and cancer cell-line models. FAM223B expression is associated with patient survival in 12 of 34 cancer types, with the highest sampling consensus in KICH. Among the 18 cancer types available for tumor–normal comparison, FAM223B is differentially expressed in 2, with the highest sampling consensus in ESCA. Additionally, FAM223B RNA expression shows 1,760 significant protein co-abundance associations, with the highest sampling consensus in BRCA. Together, these results highlight KICH, ESCA, and BRCA as cancer lineages where FAM223B shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for FAM223B — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes FAM223B survival associations across molecular data types. FAM223B RNA expression shows survival associations in the most cancer types (12). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible FAM223B RNA expression–survival associations across cancer types. High FAM223B expression shows unfavorable associations in KICH, SKCM, THCA, BLCA and LIHC, but favorable associations in ESCA. The KICH Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KICH as the clearest survival context for FAM223B RNA expression.
This table summarizes FAM223B tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 2. The strongest signals are observed in ESCA for RNA.
This table ranks reproducible tumor–normal expression differences for FAM223B. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. FAM223B shows higher tumor expression in ESCA and BRCA. The ESCA box plot shows higher FAM223B RNA expression in tumor versus normal tissue (log2 FC = +0.080, t-test p = .015).
This table shows molecular features associated with FAM223B in patient tissues and cancer cell lines. In patient samples, FAM223B shows the broadest associations at the RNA and protein expression levels, with BRCA recurring as the lineage with the largest associated feature set.
