FAM223B

Across TCGA patient cohorts, FAM223B RNA expression is significantly associated with the go_rna of many other GO terms, with 1,667 significant associations in total. STAD shows the largest number of these associations.

The most reproducible FAM223B-associated GO terms across cancer lineages are Proton transmembrane transport, Electron transport chain, and Cellular respiration. Each is linked with FAM223B in more than 3 cancer types. Because this analysis shows association rather than direction, both FAM223B-to-partner and partner-to-FAM223B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Proton transmembrane transport grouped by FAM223B-low versus FAM223B-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM223B→partner) and Y-score (partner→FAM223B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Proton transmembrane transport →	+0.040	+0.050	.001	.001	3	4
STAD	Electron transport chain →	+0.045	+0.055	<.001	<.001	3	4
STAD	Cellular respiration →	+0.047	+0.057	<.001	<.001	3	4
STAD	Ribose phosphate biosynthetic process →	+0.035	+0.040	.001	<.001	3	4
ESCA	Oxidative phosphorylation →	+0.050	+0.032	.002	.002	3	4
ESCA	Mitochondrial electron transport, NADH to ubiquinone →	+0.046	+0.037	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,667 associations by consensus.

Proton transmembrane transport by FAM223B expression — ESCA

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