MAOB

Across TCGA pan-cancer cohorts, MAOB RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of MAOB’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where MAOB RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MAOB is over-expressed in tumor, although a few such as BLCA and COAD show the opposite, repressed pattern.

KIRC, BLCA, and COAD are the cancer types where MAOB tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MAOB RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+1.148	<.001	12	view →
BLCA	Male	IV	−5.312	<.001	11	view →
COAD	All	IV	−2.287	<.001	11	view →
HNSC	Male	All	−1.957	<.001	11	view →
KICH	Male	IV	−6.173	<.001	10	view →
THCA	All	IV	−2.985	<.001	10	view →
LUAD	All	III,IV	−2.013	<.001	9	view →
UCEC	All	II,III,IV	−4.980	<.001	8	view →
LUSC	All	II,III,IV	−2.546	<.001	8	view →
BRCA	All	II,III,IV	−2.232	<.001	6	view →
STAD	All	All	−1.504	<.001	5	view →
KIRP	All	All	−0.966	.005	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

MAOB–KIRC

Open the KIRC breakdown →