MANBA

Across TCGA cell cohorts, MANBA mutation is significantly associated with the RNA expression of many other genes, with 132 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MANBA-associated genes across cancer lineages are OR2AP1, OR52N5, and RBMY1A1. Each is linked with MANBA in more than 1 cancer types. Because this analysis shows association rather than direction, both MANBA-to-partner and partner-to-MANBA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2AP1 grouped by MANBA-low versus MANBA-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MANBA→partner) and Y-score (partner→MANBA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	OR2AP1 →	+0.021	+5.196	.001	.005	3	1
OVARY	OR52N5 →	+0.056	+5.196	<.001	.005	3	1
OVARY	RBMY1A1 →	+0.143	+5.807	<.001	.001	3	1
CNS	PRM3 →	+0.106	+4.169	<.001	.008	3	1
LARGE_INTESTINE	SAMM50 →	+0.500	+3.364	.005	.002	3	1
LARGE_INTESTINE	FAH →	-0.977	-3.278	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 132 associations by consensus.

OR2AP1 by MANBA expression — OVARY

Explore this box plot interactively →