MANBA

Across TCGA pan-cancer cohorts, MANBA RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of MANBA’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where MANBA RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MANBA is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.

HNSC, KIRC, and LIHC are the cancer types where MANBA tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MANBA RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	IV	+1.820	<.001	12	view →
KIRC	Male	IV	+0.742	<.001	12	view →
LIHC	All	II,III,IV	+0.772	<.001	8	view →
STAD	Male	II,III,IV	+0.958	<.001	6	view →
BRCA	All	II,III,IV	+0.341	<.001	6	view →
LUAD	All	IV	−0.884	.021	5	view →
COAD	Male	All	+0.608	<.001	5	view →
CHOL	All	All	+1.916	<.001	3	view →
BLCA	All	All	+0.468	.034	3	view →
LUSC	All	III,IV	−0.681	.024	2	view →
KIRP	All	All	+0.347	.014	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

MANBA–HNSC

Open the HNSC breakdown →