MALT1

Across TCGA patient cohorts, MALT1 mutation is significantly associated with the RNA expression of many other genes, with 1,559 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MALT1-associated genes across cancer lineages are RNY1P7, OR10AA1P, and SHISA5P1. Each is linked with MALT1 in more than 2 cancer types. Because this analysis shows association rather than direction, both MALT1-to-partner and partner-to-MALT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNY1P7 grouped by MALT1-low versus MALT1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MALT1→partner) and Y-score (partner→MALT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNY1P7 →	+0.114	+4.186	<.001	.007	3	3
LIHC	OR10AA1P →	+0.054	+4.758	<.001	.006	3	2
LIHC	SHISA5P1 →	+0.104	+4.489	<.001	.005	3	2
OV	MIR4716 →	+0.521	+4.991	<.001	.009	3	2
UCEC	HARBI1 →	+0.337	+2.839	.005	.001	3	2
UCEC	RNU6ATAC30P →	+0.340	+2.254	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,559 associations by consensus.

RNY1P7 by MALT1 expression — SKCM

Explore this box plot interactively →