Q-omics provides the consensus-scored SHISA5P1 profile across patient tissues and cancer cell-line models. SHISA5P1 expression is associated with patient survival in 10 of 34 cancer types, with the highest sampling consensus in LUAD. Among the 18 cancer types available for tumor–normal comparison, SHISA5P1 is differentially expressed in 2, with the highest sampling consensus in COAD. Additionally, SHISA5P1 RNA expression shows 6,640 significant pathway-activity associations, with the highest sampling consensus in STAD. Together, these results highlight LUAD, COAD, and STAD as cancer lineages where SHISA5P1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for SHISA5P1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes SHISA5P1 survival associations across molecular data types. SHISA5P1 RNA expression shows survival associations in the most cancer types (10). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible SHISA5P1 RNA expression–survival associations across cancer types. High SHISA5P1 expression shows unfavorable associations in LUAD, LAML, COAD, LGG and THCA, but favorable associations in CESC. The LUAD Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .001). Together, the overview and detailed table identify LUAD as the clearest survival context for SHISA5P1 RNA expression.
This table summarizes SHISA5P1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 2. The strongest signals are observed in COAD for RNA.
This table ranks reproducible tumor–normal expression differences for SHISA5P1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. SHISA5P1 shows higher tumor expression in COAD and HNSC. The COAD box plot shows higher SHISA5P1 RNA expression in tumor versus normal tissue (log2 FC = +0.201, t-test p = .007).
This table shows molecular features associated with SHISA5P1 in patient tissues and cancer cell lines. In patient samples, SHISA5P1 shows the broadest associations at the RNA and protein expression levels, with STAD recurring as the lineage with the largest associated feature set.
