Across TCGA pan-cancer cohorts, SHISA5P1 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of SHISA5P1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where SHISA5P1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SHISA5P1 is over-expressed in tumor.

COAD and HNSC are the cancer types where SHISA5P1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SHISA5P1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	+0.201	.007	4	view →
HNSC	All	II,III,IV	+0.036	.045	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: SHISA5P1 RNA expression & survival · all SHISA5P1 data types