Q-omics provides the consensus-scored MAILR profile across patient tissues and cancer cell-line models. MAILR expression is associated with patient survival in 22 of 34 cancer types, with the highest sampling consensus in UVM. Among the 18 cancer types available for tumor–normal comparison, MAILR is differentially expressed in 12, with the highest sampling consensus in KIRC. Additionally, MAILR RNA expression shows 18,068 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight UVM, and KIRC as cancer lineages where MAILR shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for MAILR — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes MAILR survival associations across molecular data types. MAILR RNA expression shows survival associations in the most cancer types (22). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible MAILR RNA expression–survival associations across cancer types. High MAILR expression shows unfavorable associations in UVM, KIRP, COAD and CESC, but favorable associations in ACC and UCEC. The UVM Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify UVM as the clearest survival context for MAILR RNA expression.
This table summarizes MAILR tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 12. The strongest signals are observed in KIRC for RNA.
This table ranks reproducible tumor–normal expression differences for MAILR. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. MAILR shows lower tumor expression in KIRC, THCA, UCEC and KICH and higher tumor expression in LIHC and LUAD. The KIRC box plot shows higher MAILR RNA expression in normal versus tumor tissue (log2 FC = −0.532, t-test p < 0.001).
This table shows molecular features associated with MAILR in patient tissues and cancer cell lines. In patient samples, MAILR shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set.
