MAILR

Across TCGA pan-cancer cohorts, MAILR RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated MAILR data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher MAILR RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MAILR expression acts as an unfavorable survival marker, although some lineages such as ACC and UCEC show a favorable association.

UVM, ACC, and KIRP are the cancer types where MAILR RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	II,III,IV	0.281	0.677	<.001	107	view →
ACC	OS	Median	IV	0.842	0.244	.001	72	view →
KIRP	OS	Tertile	All	0.485	0.827	<.001	61	view →
UCEC	OS	Quartile	III,IV	0.914	0.719	.008	48	view →
COAD	DFS	Quartile	II,III,IV	0.693	0.848	.003	41	view →
CESC	DFS	Tertile	All	0.743	0.884	<.001	26	view →
LGG	OS	Quartile	All	0.933	0.825	.003	20	view →
DLBC	DFS	Median	II,III,IV	0.971	0.567	.016	12	view →
KICH	DFS	Median	III,IV	0.388	0.894	.009	11	view →
LIHC	DFS	Quartile	II,III,IV	0.261	0.571	.026	10	view →
BLCA	DFS	Median	III,IV	0.476	0.252	.013	6	view →
THCA	DFS	Quartile	IV	0.478	0.865	.015	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

MAILR–UVM (DFS)

Open the UVM breakdown →