MAGI1

Across TCGA patient cohorts, MAGI1 mutation is significantly associated with the RNA expression of many other genes, with 6,744 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAGI1-associated genes across cancer lineages are UQCRH, DEPDC1, and OIP5. Each is linked with MAGI1 in more than 5 cancer types. Because this analysis shows association rather than direction, both MAGI1-to-partner and partner-to-MAGI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UQCRH grouped by MAGI1-low versus MAGI1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAGI1→partner) and Y-score (partner→MAGI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	UQCRH →	+0.560	+2.357	<.001	.003	3	6
LUAD	DEPDC1 →	+0.934	+3.468	<.001	.002	3	6
UCEC	OIP5 →	+0.680	+1.306	<.001	<.001	3	5
LUAD	AUNIP →	+0.695	+2.333	.001	.003	3	5
LUAD	KIF23 →	+0.895	+3.477	<.001	.002	3	5
LUAD	KIF11 →	+0.676	+2.602	.008	.006	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,744 associations by consensus.

UQCRH by MAGI1 expression — LUAD

Explore this box plot interactively →