MAGI1

Across TCGA pan-cancer cohorts, MAGI1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of MAGI1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where MAGI1 RNA is repressed in tumor relative to normal tissue. In most cancer types MAGI1 is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

THCA, KIRC, and HNSC are the cancer types where MAGI1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MAGI1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−1.598	<.001	11	view →
KIRC	Male	II,III,IV	−0.973	<.001	11	view →
HNSC	Male	II,III,IV	−0.854	<.001	10	view →
LUAD	Female	II,III,IV	−1.251	<.001	9	view →
KIRP	Male	III,IV	−1.172	<.001	9	view →
COAD	Female	II,III,IV	−0.715	<.001	7	view →
LUSC	Female	II,III,IV	−1.818	<.001	6	view →
BRCA	All	III,IV	−0.994	<.001	6	view →
READ	All	All	−0.701	.013	2	view →
CHOL	Female	All	+0.683	.001	2	view →
BLCA	Male	All	−0.617	.030	2	view →
STAD	Male	II,III,IV	+0.492	.026	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

MAGI1–THCA

Open the THCA breakdown →