MAGI1

Across TCGA pan-cancer cohorts, MAGI1 RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated MAGI1 data layer compared with 11 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher MAGI1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated MAGI1 expression acts as an unfavorable survival marker, although some lineages such as KIRC and SCLC show a favorable association.

KIRC, ACC, and SCLC are the cancer types where MAGI1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.701	0.564	<.001	112	view →
ACC	DFS	Median	All	0.233	0.654	<.001	102	view →
SCLC	DFS	Median	II,III,IV	0.748	0.435	<.001	78	view →
HNSC	DFS	Quartile	All	0.800	0.600	<.001	69	view →
BRCA	DFS	Median	III,IV	0.940	0.810	<.001	66	view →
STAD	DFS	Quartile	II,III,IV	0.724	0.505	.006	41	view →
UCS	DFS	Median	IV	0.909	0.416	.008	30	view →
COAD	OS	Tertile	III,IV	0.935	0.614	<.001	24	view →
LUAD	DFS	Tertile	All	0.845	0.713	.012	14	view →
MESO	OS	Tertile	All	0.273	0.462	.017	12	view →
GBM	DFS	Tertile	All	0.436	0.241	.012	12	view →
LUSC	DFS	Median	III,IV	0.523	0.916	.009	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

MAGI1–KIRC (OS)

Open the KIRC breakdown →