MAGI1

Across TCGA patient cohorts, MAGI1 mutation is significantly associated with the total protein of many other genes, with 70 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAGI1-associated genes across cancer lineages are Cyclin-B1, FoxM1, and Caspase-7-cleavedD198. Each is linked with MAGI1 in more than 4 cancer types. Because this analysis shows association rather than direction, both MAGI1-to-partner and partner-to-MAGI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by MAGI1-low versus MAGI1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAGI1→partner) and Y-score (partner→MAGI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Cyclin-B1 →	+0.519	+1.774	.004	.008	3	5
LUAD	FoxM1 →	+0.273	+3.334	.013	.005	3	3
COAD	Caspase-7-cleavedD198 →	+0.960	+3.906	<.001	<.001	2	4
UCEC	4E-BP1 →	+0.235	+1.093	.001	.012	3	3
COAD	ACC1 →	+0.328	+1.906	.013	.014	3	3
COAD	Claudin-7 →	+0.647	+1.774	.003	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 70 associations by consensus.

Cyclin-B1 by MAGI1 expression — COAD

Explore this box plot interactively →