MAGI1

Across TCGA cell cohorts, MAGI1 mutation is significantly associated with the RNA expression of many other genes, with 586 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MAGI1-associated genes across cancer lineages are ADH1B, TCP10L2, and NR2C1. Each is linked with MAGI1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAGI1-to-partner and partner-to-MAGI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADH1B grouped by MAGI1-low versus MAGI1-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAGI1→partner) and Y-score (partner→MAGI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	ADH1B →	+0.603	+3.491	.001	.008	3	2
CNS	TCP10L2 →	+0.034	+2.887	.004	.005	3	2
LARGE_INTESTINE	NR2C1 →	+0.465	+3.087	<.001	.006	3	2
SKIN	CELA3A →	+0.016	+2.462	<.001	.004	3	2
SKIN	TBC1D3H →	+0.212	+2.288	.004	.002	3	2
OVARY	OR4C6 →	+0.085	+3.791	.004	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 586 associations by consensus.

ADH1B by MAGI1 expression — PANCREAS

Explore this box plot interactively →