MAGEB4

Across TCGA cell cohorts, MAGEB4 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MAGEB4-associated genes across cancer lineages are KCNK17, KIR2DS4, and FAM47C. Each is linked with MAGEB4 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAGEB4-to-partner and partner-to-MAGEB4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KCNK17 grouped by MAGEB4-low versus MAGEB4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAGEB4→partner) and Y-score (partner→MAGEB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	KCNK17 →	+0.070	+3.466	<.001	.009	3	1
LARGE_INTESTINE	KIR2DS4 →	+0.007	+3.345	<.001	.007	3	1
SKIN	FAM47C →	+0.006	+4.977	<.001	.007	3	1
LARGE_INTESTINE	NCR3 →	+0.147	+3.554	.001	.007	2	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

KCNK17 by MAGEB4 expression — LARGE_INTESTINE

Explore this box plot interactively →