MAGEA8

Across TCGA cell cohorts, MAGEA8 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MAGEA8-associated genes across cancer lineages are PDZRN4, ACER1, and PABPC1L2B. Each is linked with MAGEA8 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAGEA8-to-partner and partner-to-MAGEA8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDZRN4 grouped by MAGEA8-low versus MAGEA8-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAGEA8→partner) and Y-score (partner→MAGEA8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PDZRN4 →	+0.023	+4.332	<.001	.005	3	1
LARGE_INTESTINE	ACER1 →	+0.159	+3.823	<.001	.006	3	1
LARGE_INTESTINE	PABPC1L2B →	+0.022	+4.437	<.001	.004	3	1
LARGE_INTESTINE	QRFPR →	+1.035	+3.854	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

PDZRN4 by MAGEA8 expression — LARGE_INTESTINE

Explore this box plot interactively →