MAGEA8

Across TCGA pan-cancer cohorts, MAGEA8 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of MAGEA8’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where MAGEA8 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MAGEA8 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, THCA, and LUSC are the cancer types where MAGEA8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MAGEA8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+0.135	<.001	8	view →
THCA	Female	II,III,IV	−0.130	<.001	7	view →
LUSC	All	II,III,IV	+0.125	.009	3	view →
LIHC	All	All	+0.479	.004	2	view →
KICH	All	All	−0.045	.009	2	view →
LUAD	All	All	+0.189	.049	1	view →
KIRC	All	All	+0.018	.043	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

MAGEA8–HNSC

Open the HNSC breakdown →