MAGEA2B

Across TCGA cell cohorts, MAGEA2B mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible MAGEA2B-associated genes across cancer lineages are HAO1, MYL7, and MYL3. Each is linked with MAGEA2B in more than 1 cancer types. Because this analysis shows association rather than direction, both MAGEA2B-to-partner and partner-to-MAGEA2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HAO1 grouped by MAGEA2B-low versus MAGEA2B-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAGEA2B→partner) and Y-score (partner→MAGEA2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	HAO1 →	+0.170	+3.132	<.001	.009	3	1
LUNG_NSCLC_LUAD	MYL7 →	+0.354	+3.464	.006	.006	3	1
LUNG_NSCLC_LUAD	MYL3 →	+0.809	+3.672	<.001	.005	3	1
LUNG_NSCLC_LUAD	XAGE5 →	+0.881	+3.189	<.001	.007	3	1
LUNG_NSCLC_LUAD	CETN1 →	+0.005	+3.944	<.001	.006	3	1
LUNG_NSCLC_LUAD	ELOA3DP →	+0.098	+3.142	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

HAO1 by MAGEA2B expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →