MAGEA2B

Across TCGA pan-cancer cohorts, MAGEA2B RNA is linked to patient survival in 13 of 34 cancer types, making it the most broadly survival-associated MAGEA2B data layer.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher MAGEA2B RNA is associated with worse overall survival. In most high-consensus cancer types, elevated MAGEA2B expression acts as an unfavorable survival marker, although some lineages such as SKCM and BLCA show a favorable association.

COAD, KIRC, and KIRP are the cancer types where MAGEA2B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Tertile	All	0.247	0.582	<.001	105	view →
KIRC	DFS	Tertile	IV	0.155	0.631	<.001	90	view →
KIRP	DFS	Tertile	III,IV	0.174	0.721	<.001	57	view →
READ	DFS	Tertile	III,IV	0.096	0.773	<.001	54	view →
LIHC	DFS	Tertile	II,III,IV	0.273	0.451	.014	51	view →
UVM	OS	Tertile	All	0.305	0.796	.001	45	view →
CESC	OS	Tertile	IV	0.121	0.591	.029	36	view →
MESO	OS	Tertile	II,III,IV	0.350	0.574	.015	36	view →
ACC	DFS	Tertile	All	0.068	0.667	.005	36	view →
SKCM	OS	Median	All	0.818	0.752	.010	13	view →
BLCA	DFS	Quartile	III,IV	0.526	0.288	.017	8	view →
LUAD	DFS	Quartile	IV	0.426	0.708	.026	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

MAGEA2B–COAD (OS)

Open the COAD breakdown →