MAEA

Across TCGA patient cohorts, MAEA mutation is significantly associated with the RNA expression of many other genes, with 2,820 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAEA-associated genes across cancer lineages are CFC1B, ATF4P1, and TOMM22. Each is linked with MAEA in more than 2 cancer types. Because this analysis shows association rather than direction, both MAEA-to-partner and partner-to-MAEA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CFC1B grouped by MAEA-low versus MAEA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAEA→partner) and Y-score (partner→MAEA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CFC1B →	+0.009	+2.832	.005	.001	3	3
KIRP	ATF4P1 →	+0.053	+5.497	<.001	.004	3	2
UCEC	TOMM22 →	+0.358	+2.120	<.001	<.001	3	2
UCEC	INTS10 →	+0.345	+3.021	.001	<.001	3	2
UCEC	MED31 →	+0.502	+2.401	<.001	<.001	3	2
UCEC	LMNB1 →	+0.496	+1.761	.008	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,820 associations by consensus.

CFC1B by MAEA expression — UCEC

Explore this box plot interactively →