Q-omics provides the consensus-scored MADD-AS1 profile across patient tissues and cancer cell-line models. MADD-AS1 expression is associated with patient survival in 22 of 34 cancer types, with the highest sampling consensus in LGG. Among the 18 cancer types available for tumor–normal comparison, MADD-AS1 is differentially expressed in 6, with the highest sampling consensus in STAD. Additionally, MADD-AS1 RNA expression shows 17,237 significant gene co-expression associations, with the highest sampling consensus in THYM. Together, these results highlight LGG, STAD, and THYM as cancer lineages where MADD-AS1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for MADD-AS1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes MADD-AS1 survival associations across molecular data types. MADD-AS1 RNA expression shows survival associations in the most cancer types (22). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible MADD-AS1 RNA expression–survival associations across cancer types. High MADD-AS1 expression shows unfavorable associations in HNSC and LIHC, but favorable associations in LGG, SKCM, STAD and ESCA. The LGG Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify LGG as the clearest survival context for MADD-AS1 RNA expression.
This table summarizes MADD-AS1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 6. The strongest signals are observed in STAD for RNA.
This table ranks reproducible tumor–normal expression differences for MADD-AS1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. MADD-AS1 shows lower tumor expression in THCA, KICH and LUAD and higher tumor expression in STAD, KIRC and COAD. The STAD box plot shows higher MADD-AS1 RNA expression in tumor versus normal tissue (log2 FC = +0.178, t-test p = .023).
This table shows molecular features associated with MADD-AS1 in patient tissues and cancer cell lines. In patient samples, MADD-AS1 shows the broadest associations at the RNA and protein expression levels, with THYM recurring as the lineage with the largest associated feature set.
