MADD-AS1

Across TCGA pan-cancer cohorts, MADD-AS1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated MADD-AS1 data layer.

The strongest signal is observed in brain lower grade glioma (LGG), where higher MADD-AS1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated MADD-AS1 expression acts as an unfavorable survival marker, although some lineages such as LGG and SKCM show a favorable association.

LGG, HNSC, and SKCM are the cancer types where MADD-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	DFS	Median	All	0.822	0.655	<.001	53	view →
HNSC	OS	Quartile	III,IV	0.466	0.749	.001	39	view →
SKCM	OS	Quartile	III,IV	0.841	0.631	.001	31	view →
LIHC	OS	Tertile	II,III,IV	0.561	0.747	.014	24	view →
STAD	OS	Median	All	0.628	0.498	.015	21	view →
ESCA	OS	Median	III,IV	0.527	0.288	.002	18	view →
LUSC	DFS	Median	IV	0.134	0.827	.014	18	view →
READ	OS	Tertile	II,III,IV	0.716	0.250	.002	17	view →
UCS	DFS	Tertile	III,IV	0.533	0.170	.039	16	view →
PAAD	DFS	Tertile	II,III,IV	0.520	0.275	.027	12	view →
PCPG	OS	Median	All	0.937	1.000	.021	11	view →
OV	OS	Median	IV	0.615	0.854	.015	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

MADD-AS1–LGG (DFS)

Open the LGG breakdown →