MACROH2A2

Across TCGA patient cohorts, MACROH2A2 protein abundance is significantly associated with the RNA expression of many other genes, with 14,331 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible MACROH2A2-associated genes across cancer lineages are ST6GAL2, ACVR2A, and OMD. Each is linked with MACROH2A2 in more than 6 cancer types. Because this analysis shows association rather than direction, both MACROH2A2-to-partner and partner-to-MACROH2A2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MACROH2A2 versus ST6GAL2 in HNSC, with a Pearson correlation of 0.37.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MACROH2A2→partner) and Y-score (partner→MACROH2A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ST6GAL2 →	+1.321	+0.409	<.001	<.001	3	7
PDAC	ACVR2A →	+0.671	+0.464	<.001	<.001	3	6
BRCA	OMD →	+1.482	+0.588	<.001	<.001	3	6
OV	SMO →	+1.033	+0.739	<.001	<.001	3	6
LSCC	NREP →	+0.538	+0.271	<.001	<.001	3	6
UCEC	NKD1 →	+2.809	+0.727	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,331 associations by consensus.

MACROH2A2 vs ST6GAL2 — HNSC

Explore this scatter interactively →