MACROH2A2

Across TCGA pan-cancer cohorts, MACROH2A2 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of MACROH2A2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where MACROH2A2 RNA is repressed in tumor relative to normal tissue. In most cancer types MACROH2A2 is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

KICH, KIRC, and BLCA are the cancer types where MACROH2A2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MACROH2A2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	All	−2.550	<.001	11	view →
KIRC	Female	II,III,IV	−1.253	<.001	11	view →
BLCA	All	All	+0.839	<.001	8	view →
LUSC	Female	All	+2.117	<.001	6	view →
UCEC	All	II,III,IV	+1.155	<.001	6	view →
STAD	All	All	−0.846	.001	4	view →
THCA	Female	All	+0.388	<.001	4	view →
LIHC	All	II,III,IV	+1.198	<.001	3	view →
HNSC	Male	IV	+0.776	.038	2	view →
CHOL	All	All	+1.880	.013	1	view →
LUAD	All	All	+0.422	.018	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

MACROH2A2–KICH

Open the KICH breakdown →