MACROH2A2

Across TCGA pan-cancer cohorts, MACROH2A2 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated MACROH2A2 data layer compared with 4 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in brain lower grade glioma (LGG), where higher MACROH2A2 RNA is associated with better overall survival. In most high-consensus cancer types, elevated MACROH2A2 expression acts as an unfavorable survival marker, although some lineages such as LGG and UCS show a favorable association.

LGG, ACC, and UCS are the cancer types where MACROH2A2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	OS	Median	All	0.523	0.329	<.001	48	view →
ACC	DFS	Median	All	0.235	0.640	<.001	37	view →
UCS	OS	Median	II,III,IV	0.602	0.208	.003	30	view →
OV	DFS	Tertile	IV	0.686	0.321	<.001	30	view →
READ	DFS	Median	II,III,IV	0.228	0.829	<.001	30	view →
LAML	DFS	Median	All	0.471	0.669	.003	28	view →
DLBC	DFS	Median	IV	1.000	0.281	.005	24	view →
UVM	DFS	Median	II,III,IV	0.769	0.388	.001	22	view →
KIRP	DFS	Quartile	II,III,IV	0.878	0.526	.010	21	view →
THYM	OS	Median	II,III,IV	0.886	1.000	.011	14	view →
ESCA	DFS	Median	II,III,IV	1.000	0.399	.013	13	view →
SKCM	OS	Quartile	IV	0.699	0.188	.001	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

MACROH2A2–LGG (OS)

Open the LGG breakdown →