MACROH2A2

Across TCGA patient cohorts, MACROH2A2 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MACROH2A2-associated genes across cancer lineages are EGFR_pY1068, Acetyl-a-Tubulin-Lys40, and INPP4B. Each is linked with MACROH2A2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MACROH2A2-to-partner and partner-to-MACROH2A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by MACROH2A2-low versus MACROH2A2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MACROH2A2→partner) and Y-score (partner→MACROH2A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.231	-2.000	.041	.032	3	2
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.584	+2.700	.010	.006	3	2
UCEC	INPP4B →	-0.289	-2.321	.047	.033	3	2
UCEC	N-Ras →	-0.114	-1.986	.033	.032	3	2
UCEC	ATM →	-0.784	-2.700	<.001	.006	3	2
UCEC	4E-BP1 →	+0.456	+3.199	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

EGFR_pY1068 by MACROH2A2 expression — UCEC

Explore this box plot interactively →