MACROH2A2

Across TCGA cell cohorts, MACROH2A2 mutation is significantly associated with the mutation status of many other genes, with 1,995 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MACROH2A2-associated genes across cancer lineages are POU6F2, PPM1G, and TFAP2A. Each is linked with MACROH2A2 in more than 2 cancer types. Because this analysis shows association rather than direction, both MACROH2A2-to-partner and partner-to-MACROH2A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, POU6F2 grouped by MACROH2A2-low versus MACROH2A2-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MACROH2A2→partner) and Y-score (partner→MACROH2A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	POU6F2 →	+4.429	+5.247	.005	.005	1	3
BLOOD_Lymphoma	PPM1G →	+6.014	+6.014	.001	.001	1	3
BLOOD_Lymphoma	TFAP2A →	+5.014	+5.584	.003	.003	1	3
OVARY	IGF1R →	+4.415	+4.977	.007	.007	1	3
BLOOD_Lymphoma	ZIC1 →	+4.014	+4.969	.008	.008	1	3
BLOOD_Lymphoma	EYA3 →	+6.014	+6.014	.001	.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,995 associations by consensus.

POU6F2 by MACROH2A2 expression — BLOOD_Lymphoma

Explore this box plot interactively →