MACIR

Across TCGA patient cohorts, MACIR mutation is significantly associated with the RNA expression of many other genes, with 1,337 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MACIR-associated genes across cancer lineages are RNU6-1305P, LINC01400, and NUP35P2. Each is linked with MACIR in more than 1 cancer types. Because this analysis shows association rather than direction, both MACIR-to-partner and partner-to-MACIR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1305P grouped by MACIR-low versus MACIR-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MACIR→partner) and Y-score (partner→MACIR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	RNU6-1305P →	+0.307	+4.758	<.001	.006	3	2
LIHC	LINC01400 →	+0.038	+5.008	<.001	.004	3	2
COAD	NUP35P2 →	+0.127	+4.917	<.001	.003	3	2
COAD	RPSAP57 →	+0.083	+3.588	.001	.007	3	2
COAD	GPR32 →	+0.042	+4.145	.002	.002	3	2
UCEC	RNU6-618P →	+0.290	+2.800	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,337 associations by consensus.

RNU6-1305P by MACIR expression — LIHC

Explore this box plot interactively →