MACIR

Across TCGA pan-cancer cohorts, MACIR RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of MACIR’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where MACIR RNA is repressed in tumor relative to normal tissue. In most cancer types MACIR is over-expressed in tumor, although a few such as THCA and COAD show the opposite, repressed pattern.

THCA, COAD, and BLCA are the cancer types where MACIR tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MACIR RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−1.402	<.001	9	view →
COAD	Female	All	−1.245	<.001	9	view →
BLCA	All	All	+0.855	.002	8	view →
KIRP	All	III,IV	+0.745	.001	7	view →
BRCA	All	III,IV	+0.963	<.001	6	view →
CHOL	Female	All	+3.420	<.001	5	view →
LIHC	Female	All	+1.129	<.001	5	view →
LUAD	Male	All	+0.762	<.001	5	view →
HNSC	Male	All	+0.585	<.001	5	view →
KIRC	Male	All	−0.426	.001	5	view →
KICH	Female	All	+1.080	<.001	4	view →
LUSC	Male	All	+0.489	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

MACIR–THCA

Open the THCA breakdown →