MACIR

Across TCGA pan-cancer cohorts, MACIR RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated MACIR data layer compared with 7 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher MACIR RNA is associated with worse overall survival. In most high-consensus cancer types, elevated MACIR expression acts as an unfavorable survival marker, although some lineages such as READ and KIRC show a favorable association.

ACC, UCEC, and LIHC are the cancer types where MACIR RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Tertile	All	0.739	0.978	<.001	92	view →
UCEC	DFS	Tertile	All	0.547	0.813	.001	82	view →
LIHC	OS	Median	All	0.611	0.759	<.001	72	view →
READ	DFS	Median	All	0.738	0.342	.001	58	view →
MESO	OS	Tertile	All	0.402	0.717	<.001	58	view →
KIRC	DFS	Median	All	0.747	0.502	<.001	43	view →
KIRP	DFS	Tertile	All	0.828	0.956	<.001	31	view →
UVM	DFS	Median	III,IV	0.284	0.907	.002	30	view →
ESCA	OS	Quartile	II,III,IV	0.344	0.605	.003	30	view →
SCLC	OS	Median	All	0.215	0.503	<.001	27	view →
SKCM	DFS	Median	III,IV	0.377	0.677	.001	24	view →
LUAD	DFS	Quartile	All	0.732	0.843	.008	21	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

MACIR–ACC (OS)

Open the ACC breakdown →